NIA Mouse Gene Index, mm9

5283. U029415
Annotation: a disintegrin and metallopeptidase domain 8     Gene?: Yes     Source: NM_007403    Symbol:  Adam8
Chromosome: chr7   Strand: -    Start: 147164830    End: 147178461
List: Negative strand of chr7 (N=5573)

Genome Browsers: UCSC -
View Regulatory Regions


Exon structure

Domains
IPR002870 - Peptidase M12B, propeptide
IPR006706 - Extensin-like region
IPR010801 - Fibronectin-attachment
IPR004243 - Minor capsid protein VI
IPR001590 - Peptidase M12B, ADAM/reprolysin
IPR006745 - Protein of unknown function DUF605
IPR001762 - Blood coagulation inhibitor, Disintegrin
IPR010820 - Protein of unknown function DUF1421
IPR006586 - ADAM, cysteine-rich
IPR010616 - Protein of unknown function DUF1210
IPR014840 - Histone promoter control 2 (HPC2)

GO-Ontologies
GO:0008237 - metallopeptidase activity
GO:0071456 - cellular response to hypoxia
GO:0032127 - dense core granule membrane
GO:0006508 - proteolysis
GO:0033089 - positive regulation of T cell differentiation in thymus
GO:0002523 - leukocyte migration involved in inflammatory response
GO:0007160 - cell-matrix adhesion
GO:0032010 - phagolysosome
GO:0005737 - cytoplasm
GO:0051092 - positive regulation of NF-kappaB transcription factor activity
GO:0050729 - positive regulation of inflammatory response
GO:0005515 - protein binding
GO:0048247 - lymphocyte chemotaxis
GO:0000902 - cell morphogenesis
GO:0042581 - specific granule
GO:0030335 - positive regulation of cell migration
GO:0005509 - calcium ion binding
GO:0016021 - integral to membrane
GO:0006944 - cellular membrane fusion
GO:0043534 - blood vessel endothelial cell migration
GO:0007229 - integrin-mediated signaling pathway
GO:0016020 - membrane
GO:0071133 - alpha9-beta1 integrin-ADAM8 complex
GO:0001525 - angiogenesis
GO:2000309 - positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:0070820 - tertiary granule
GO:0045780 - positive regulation of bone resorption
GO:0004222 - metalloendopeptidase activity
GO:0002687 - positive regulation of leukocyte migration
GO:0051897 - positive regulation of protein kinase B signaling cascade
GO:0016787 - hydrolase activity
GO:0022407 - regulation of cell-cell adhesion
GO:0070245 - positive regulation of thymocyte apoptosis
GO:0006954 - inflammatory response
GO:0009986 - cell surface
GO:0005887 - integral to plasma membrane
GO:0046872 - metal ion binding
GO:0002675 - positive regulation of acute inflammatory response
GO:0048729 - tissue morphogenesis
GO:0043524 - negative regulation of neuron apoptosis
GO:0005178 - integrin binding
GO:0071594 - thymocyte aggregation
GO:0016337 - cell-cell adhesion
GO:0008270 - zinc ion binding
GO:0045670 - regulation of osteoclast differentiation
GO:0002102 - podosome
GO:0045785 - positive regulation of cell adhesion
GO:0005886 - plasma membrane
GO:0050839 - cell adhesion molecule binding
GO:0002693 - positive regulation of cellular extravasation
GO:0051044 - positive regulation of membrane protein ectodomain proteolysis
GO:0008233 - peptidase activity
GO:0035419 - activation of MAPK activity involved in innate immune response