NIA Mouse Gene Index, mm9

2666. U012823
Annotation: transformation related protein 53     Gene?: Yes     Source: NM_001127233    Symbol:  Trp53
Chromosome: chr11   Strand: +    Start: 69393849    End: 69405375
List: Positive strand of chr11 (N=6082)

Genome Browsers: UCSC -
View Regulatory Regions


Exon structure

Domains
IPR010991 - p53, tetramerisation
IPR013872 - p53 transactivation domain (TAD)
IPR011615 - p53, DNA-binding

GO-Ontologies
GO:0008134 - transcription factor binding
GO:0001085 - RNA polymerase II transcription factor binding
GO:0006974 - response to DNA damage stimulus
GO:0048662 - negative regulation of smooth muscle cell proliferation
GO:0072332 - signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0071158 - positive regulation of cell cycle arrest
GO:0005829 - cytosol
GO:0003677 - DNA binding
GO:0007179 - transforming growth factor beta receptor signaling pathway
GO:0035035 - histone acetyltransferase binding
GO:0005515 - protein binding
GO:0042127 - regulation of cell proliferation
GO:0008022 - protein C-terminus binding
GO:0005667 - transcription factor complex
GO:0003690 - double-stranded DNA binding
GO:0051726 - regulation of cell cycle
GO:0006915 - apoptotic process
GO:0008104 - protein localization
GO:0005730 - nucleolus
GO:0007569 - cell aging
GO:0009303 - rRNA transcription
GO:0051262 - protein tetramerization
GO:0005654 - nucleoplasm
GO:0009792 - embryo development ending in birth or egg hatching
GO:0005657 - replication fork
GO:0002309 - T cell proliferation involved in immune response
GO:0006977 - DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0045892 - negative regulation of transcription, DNA-dependent
GO:0045893 - positive regulation of transcription, DNA-dependent
GO:0002326 - B cell lineage commitment
GO:2000279 - negative regulation of DNA biosynthetic process
GO:0003684 - damaged DNA binding
GO:0008156 - negative regulation of DNA replication
GO:0006355 - regulation of transcription, DNA-dependent
GO:0005625 - soluble fraction
GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway
GO:0090343 - positive regulation of cell aging
GO:0002687 - positive regulation of leukocyte migration
GO:0003700 - sequence-specific DNA binding transcription factor activity
GO:0010165 - response to X-ray
GO:0030308 - negative regulation of cell growth
GO:0047485 - protein N-terminus binding
GO:0000733 - DNA strand renaturation
GO:0006978 - DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0042771 - DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0042149 - cellular response to glucose starvation
GO:0007406 - negative regulation of neuroblast proliferation
GO:0002360 - T cell lineage commitment
GO:0016363 - nuclear matrix
GO:0051721 - protein phosphatase 2A binding
GO:0000785 - chromatin
GO:0043523 - regulation of neuron apoptosis
GO:0006461 - protein complex assembly
GO:0030330 - DNA damage response, signal transduction by p53 class mediator
GO:0071850 - mitotic cell cycle arrest
GO:0051453 - regulation of intracellular pH
GO:0006917 - induction of apoptosis
GO:0070215 - MDM2 binding
GO:0033077 - T cell differentiation in thymus
GO:0009411 - response to UV
GO:0034613 - cellular protein localization
GO:0031065 - positive regulation of histone deacetylation
GO:0016605 - PML body
GO:2000379 - positive regulation of reactive oxygen species metabolic process
GO:0043234 - protein complex
GO:0048147 - negative regulation of fibroblast proliferation
GO:0031625 - ubiquitin protein ligase binding
GO:0005737 - cytoplasm
GO:0090399 - replicative senescence
GO:0008340 - determination of adult lifespan
GO:0005524 - ATP binding
GO:0006289 - nucleotide-excision repair
GO:0045787 - positive regulation of cell cycle
GO:0044212 - transcription regulatory region DNA binding
GO:0001756 - somitogenesis
GO:0007050 - cell cycle arrest
GO:0005678 - chromatin assembly complex
GO:0042802 - identical protein binding
GO:0046902 - regulation of mitochondrial membrane permeability
GO:0050790 - regulation of catalytic activity
GO:0006351 - transcription, DNA-dependent
GO:0000790 - nuclear chromatin
GO:0007049 - cell cycle
GO:0000060 - protein import into nucleus, translocation
GO:0000739 - DNA strand annealing activity
GO:0007417 - central nervous system development
GO:0043565 - sequence-specific DNA binding
GO:0009651 - response to salt stress
GO:0051276 - chromosome organization
GO:0006302 - double-strand break repair
GO:0034644 - cellular response to UV
GO:0008635 - activation of caspase activity by cytochrome c
GO:0070245 - positive regulation of thymocyte apoptosis
GO:0043525 - positive regulation of neuron apoptosis
GO:0043066 - negative regulation of apoptotic process
GO:0035033 - histone deacetylase regulator activity
GO:0071479 - cellular response to ionizing radiation
GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation
GO:0046872 - metal ion binding
GO:0001836 - release of cytochrome c from mitochondria
GO:0031571 - mitotic cell cycle G1/S transition DNA damage checkpoint
GO:0005626 - insoluble fraction
GO:0005507 - copper ion binding
GO:0010332 - response to gamma radiation
GO:0002039 - p53 binding
GO:0001701 - in utero embryonic development
GO:0019899 - enzyme binding
GO:0090403 - oxidative stress-induced premature senescence
GO:0035264 - multicellular organism growth
GO:0007275 - multicellular organismal development
GO:0051087 - chaperone binding
GO:0042493 - response to drug
GO:0005783 - endoplasmic reticulum
GO:0000122 - negative regulation of transcription from RNA polymerase II promoter
GO:0008285 - negative regulation of cell proliferation
GO:0042981 - regulation of apoptotic process
GO:0005739 - mitochondrion
GO:0002020 - protease binding
GO:0019901 - protein kinase binding
GO:0005634 - nucleus
GO:0007369 - gastrulation
GO:0006983 - ER overload response
GO:0003682 - chromatin binding
GO:0043065 - positive regulation of apoptotic process
GO:0045944 - positive regulation of transcription from RNA polymerase II promoter
GO:0046982 - protein heterodimerization activity